![]() ![]() Although both 4-1BB and CD27 increased production, only 4-1BB was able to prolong the duration over which cytokine was produced, and both had only modest effects on antigen sensitivity. Here, we screened for the quantitative impact of these TNFRSFs on primary human CD8 + T-cell cytokine production. The co-stimulation TNF receptor superfamily (TNFRSF) members 4-1BB, CD27, GITR and OX40 have similar signalling mechanisms raising the question of whether they have similar impacts on T-cell responses. ![]() T-cell responses to infections and cancers are regulated by co-signalling receptors grouped into the binary categories of co-stimulation or co-inhibition.
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The band released four independent albums prior to signing with Essential Records. Led by Wade Joye and Chris Brown, Elevation Worship began in 2007 at Elevation Church in Charlotte, North Carolina. |
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